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The heterotetradimers are formed pursuing the conversation of UPK2 and UPK3A moieties of your heterodimers. Following assembly within the endoplasmic reticulum as well as the Golgi, six heterotetradimers arranged in inner and outer rings68 variety a 16 nm AUM particle or plaque (Fig. three), packaged into DFVs and delivered to the apical membran